San Francisco 49ers vs. Jacksonville Jaguars Start Em Sit Em Week 4 2025 Fantasy Football Guide

49ers

The 49ers come in undefeated at 3-0, while the Jaguars are 2-1 and proving they can hang with anyone. Both squads have won close games, and both are capable of lighting up the scoreboard. That means fantasy managers should see plenty of viable options on both sides of the ball.

This game has all the makings of a fun matchup, but will Trevor Lawrence be consistent? Let’s break it down.

🔥 Starts

  • Christian McCaffrey (RB, 49ers) 🔥
  • McCaffrey has been relatively quiet on the ground, but he’s been elite through the air, taking on even more responsibility with George Kittle sidelined and Jauan Jennings potentially out. Expect Kyle Shanahan to feature CMC as a receiver out of the backfield to exploit mismatches.
  • Projection: 15 carries, 67 yards, 6 catches, 74 yards, 1 TD
  • Ricky Pearsall (WR, 49ers) 💪🔥
  • Pearsall has carved out a strong WR2/flex role, but fantasy managers are waiting for him to hit pay dirt consistently. Against a Jags secondary that can be beaten, this is the week Pearsall breaks through with his first big outing.
  • Projection: 5 catches, 69 yards, 1 TD

Travis Etienne (RB, Jaguars) 🔥

Sep 21, 2025; Jacksonville, Florida, USA; Jacksonville Jaguars running back Travis Etienne Jr. (1) during pregame against the Houston Texans at EverBank Stadium. Mandatory Credit: Travis Register-Imagn Images

The 49ers’ defense is as tough as they come, but they have been surprisingly susceptible against the run this season. Etienne’s explosiveness and ability to contribute in the passing game make him a high-floor, high-ceiling option.
Projection: 18 carries, 87 yards, 1 TD, 3 catches, 22 yards

Fantasy Football Tight End Streaming Week 4: Strange as it Ever Was – Justin Edwards via X 4for4.

  • Brenton Strange (TE, Jaguars) 🔥
  • Strange has been trending up with two solid outings already, and now he gets a defense that has surrendered strong fantasy days to tight ends like Juwan Johnson and Trey McBride. He’s primed for a breakout game.
  • Projection: 6 catches, 61 yards, 1 TD

❄️ Sits

  • Jauan Jennings (WR, 49ers) ❄️
  • Jennings hasn’t practiced this week and is trending toward being a scratch. Even if he plays, he’s not more than a desperation flex option. It’s best to leave him on the bench.
  • Projection: 2 catches, 19 yards
  • Brian Thomas Jr. (WR, Jaguars) ❄️
  • Lawrence has spread the ball around effectively, which has limited Thomas’ production. With so many mouths to feed, Thomas has struggled to carve out consistent fantasy value.
  • Projection: 3 catches, 27 yards

🌙 Sleepers

  • Bhayshul Tuten (RB, Jaguars) 🌙
  • Tuten is quietly becoming a strong complement to Etienne, with one rushing and one receiving touchdown already this season. His versatility gives him sneaky flex value, especially in deeper leagues.
  • Projection: 7 carries, 33 yards, 3 catches, 26 yards, 1 TD
  • Parker Washington (WR, Jaguars) 🌙
  • Washington continues to earn targets and produce as defenses key in on other Jacksonville weapons. His steady involvement makes him an intriguing sleeper in PPR formats.
  • Projection: 5 catches, 52 yards

Parker Washington Fantasy Football Waiver Wire: Should Managers Pick Up the Jacksonville Jaguars WR This Week? -Jason Katz Via Pro Football Network

  • Mac Jones (QB, 49ers) 🌙
  • If you drafted Brock Purdy and are looking for a spot start, Mac Jones (now in Jacksonville’s system as a depth piece) is worth considering. He benefits from a QB-friendly scheme and faces a defense that has allowed other passers to have productive fantasy days.
  • Projection: 212 passing yards, 1 TD, 1 INT

Wrap-Up

The 49ers and Jaguars both bring explosive offensive talent into this matchup, making it one of the more intriguing fantasy showdowns of the week. Christian McCaffrey and Travis Etienne headline the must-starts, while Ricky Pearsall and Brenton Strange are set up for breakout performances. On the flip side, Jauan Jennings and Brian Thomas are tough to trust with limited volume. Keep an eye on sleepers like Bhayshul Tuten and Parker Washington, who could steal valuable touches. Expect a competitive, back-and-forth game that delivers plenty of fantasy fireworks.

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