Indianapolis Colts (2-0) at Tennessee Titans (0-2)  Preview, Prediction & Odds | Week 3, 2025

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Indianapolis Colts (2-0) at Tennessee Titans (0-2)
Game Details: Sunday, September 21, 1 p.m. EST
Location: Nissan Stadium, Nashville, TN
Where to Watch: CBS

The Indianapolis Colts enter Week 3 riding high with a perfect 2-0 record, sitting atop the AFC South after dramatic wins over Miami and Denver. Meanwhile, the Tennessee Titans remain winless at 0-2, desperately searching for their first victory of the season when they host Indianapolis at Nissan Stadium on Sunday.

This divisional matchup carries extra significance as both teams look to establish early momentum.. The Colts have exceeded expectations behind quarterback Daniel Jones, who has thrown for 588 yards without an interception through two games. The Titans, conversely, are still finding their identity under rookie quarterback Cam Ward, who struggled in a 33-19 home loss to the Los Angeles Rams last week.

Betting Odds

Team Spread Money Line Total
Indianapolis Colts -3.5-180Over 43.5
Tennessee Titans+3.5+152Under 43.5

** Odds Subject to Change – Courtesy of FanDuel**

Tale of The Tape

Indianapolis Colts Team Stats – Avg Per GameTennessee Titans
31Points Per Game15.5
284Passing Yards Per Game102.5
161.5Rushing Yards Per Game90
18Opponents Points Per Game Allowed26.5
169.5Opponents Pass Yards Allowed 228
98Opponents Rush Yards Allowed 150

Key Details

Sep 7, 2025; Denver, Colorado, USA; Tennessee Titans quarterback Cam Ward (1) drops back to pass against the Denver Broncos during the first half at Empower Field at Mile High. Mandatory Credit: Ron Chenoy-Imagn Images

Indianapolis Colts

The Colts’ hot start has been fueled by exceptional quarterback play and a balanced offensive attack. Daniel Jones has completed an impressive 71.4% of his passes for 588 yards, two touchdowns, and zero interceptions, posting a 111.1 passer rating that ranks among the league’s best. His ability to handle pressure has been particularly noteworthy, as evidenced in the 29-28 victory over Denver, where he completed 17 of 26 passes for 269 yards against five or more pass rushers.

Running back Jonathan Taylor has been equally impressive, averaging 6.6 yards per carry and contributing both as a rusher and receiver. In the Denver game, Taylor rushed for 165 yards on 25 carries while also making key catches, including a touchdown reception. The Colts’ offense currently ranks second in the NFL in yards per play at 6.5, showcasing the versatility that head coach Shane Steichen has implemented in his third season.

Defensively, Indianapolis has been opportunistic, recording three sacks and two interceptions in its dominant 33-8 win over Miami. Safety Cam Bynum has emerged as a playmaker with two interceptions in two games, both coming with assists from defensive tackle Grover Stewart.

Tennessee Titans

The Titans face significant challenges on both sides of the ball as they seek their first win. Rookie quarterback Cam Ward has struggled to find rhythm, completing just 19 of 33 passes for 175 yards in the loss to Los Angeles. The offensive line’s inability to provide adequate protection has hampered Ward’s development, forcing him into difficult situations throughout the early season.

Prediction

Did you know that a lot of times, there are as many Colts fans in Nashville as Titans fans? It is a good weekend road trip down I-65. A Colts win and a Grand Ole Opry visit sounds like a solid weekend.

Final Pick

Indianapolis Colts  –3.5

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