Chicago White Sox vs. Boston Red Sox Odds, Analysis, & Prediction | April 20, 2025

This Chicago White Sox vs. Boston Red Sox preview handicaps Game 3 on Sunday in Beantown with the Pale Hose looking to get their first Road win of the season. In Game 1 on Friday, Boston won 10-3 before winning 4-3 in Game 2 on Saturday. On the season, the Red Sox are 3-2 vs Chicago. Let’s look at the starting pitchers, relevant stats, series, and recent team trends, and make a pick on this AL game. Game 4 will be played on Monday.

White Sox vs Red Sox Odds

Chicago White Sox vs Boston Red Sox

• Game: Chicago White Sox at Boston Red Sox

• Date and Time: Sunday, April 20, 2025, 1:36 EDT/12:36 CDT/10:36 PDT

• Location: Fenway Park (Kentucky Bluegrass), Boston, Massachusetts

Key Stats

Chicago White Sox

The White Sox (4-16, 0-8 on the Road) are scheduled to start RHP Sean Burke (1-3, 7.56 ERA, 1.50 WHIP) as the visitors look to avoid yet another loss. Lifetime, Burke is 0-3 in his last 3 starts, allowing 6, 2, and 5 ER in setbacks to the Twins, Guardians, and A’s.

The longest he lasted in those starts was 4.1 IP, so with the size of Fenway Park and the hosts scoring 14 runs in the first two games, Burke may get rocked The worst team in MLB in 2024, the White Sox rank No. 30 in three hitting categories: Batting Average (.195), On Base Percentage (.266), and Slugging Percentage (.297) and are No. 29 in Runs (60). There are 30 teams in Major League Baseball.

White Sox Betting Trends

• The White Sox are 2-8 in their last 10 games
• Chicago has scored an AL-low 60 Runs
• The Under is 4-2-1 in the last seven White Sox games
• Chicago has lost six straight games overall (11 RF-40 RA)
• The White Sox are still winless on the Road (0-8)
• Chicago has scored just 10 Runs in the last four series meetings

Boston Red Sox

The Red Sox (12-10, 6-3 at Home) are scheduled to start RHP Tanner Houck (0-2, 9.16 ERA, 1.93 WHIP), as the 28-year-old looks for a decent start after getting shellacked by the Rays in his last outing. At Tampa in a 16-1 loss, Houck gave up 10 hits and 12 runs (11 ER) in just 2.1 IP of work after an average start to the 2025 MLB Regular Season.

If the White Sox bats are to suddenly come alive, maybe it will be here against Houck, but he was solid in the start before. With Trevor Story (.318, 5 HR), Alex Bregman (16 RBI), Wilyer Abreu (.412 OBP) and rookie Kristian Campbell (.290, 2 HR, 6 RBI), the Carmines have a nice nucleus and have been playing well of late, winning 4 games in a row heading in here.

Red Sox Betting Trends

• The Red Sox have won three straight against the White Sox
• Boston is 4-1 in the last five series meetings at Fenway Park
• The Under is 3-1-0 in the last four series meetings
• Boston is 11-6 in the month of April (1-4 in March)
• The Red Sox were 4-3 vs the White Sox in 2024
• Boston is 6-4 in the last 10 series meetings

Prediction

The White Sox were 41-121 last season, breaking the post-1900 MLB record for Losses in a season, and this year’s version may not be as bad, but still aren’t winning. Chicago won on Opening Day to get above .500 for the first time in ages, but since then, it’s been just what we all expected.

With all five teams in the AL East looking like they have a shot in this competitive division, Boston will have to win all games like this against inferior opponents. Laying 1.5 runs in the Run Line market seems like the logical approach for this one at historic Fenway Park, where we may see a lot of Runs scored on this Easter Sunday.

Final Pick

Red Sox -1.5 -124