Top MLB DFS Start‘em/Sit‘em For May 21st

top mlb dfs

Today is another week in the MLB season, and tonight’s top MLB DFS lineups could have players start it off right with winning cash prizes. Wednesday’s 16-game slate keeps the week going with a bang for fantasy players. The middle of the week is here for fantasy players, and today’s top MLB DFS lineups could have players win cash prizes tonight.

Wednesday’s games will keep the week on a hot streak with the Chicago Cubs and the Miami Marlins. Another game that fantasy players should have players in tonight’s top MLB DFS lineups should be the San Diego Padres and the Toronto Blue Jays.

The second-to-last week of May is in the midweek of the month and could be a strong day for tonight’s top MLB DFS lineups.

May 21st Top MLB DFS Lineup Starters

3B Edmundo Sosa, Philadelphia Phillies at Colorado Rockies ($4,600 – DraftKings/3,200-Fanduel)

To start Wednesday night’s top MLB DFS lineups, Edmundo Sosa of the Philadelphia Phillies should be in your lineups. During a win against the Rockies, Sosa went 4-5 with two runs, a home run, and two RBIs.

Sosa has been playing well for the Phillies and could have another good game today.  Fantasy players could see Sosa have a multi-hit game, including another home run at Coors Field tonight.

OF Cody Bellinger, Texas Rangers at New York Yankees ($4,500 – DraftKings/3,300-Fanduel)

Cody Bellinger of the New York Yankees should be in their lineups for Wednesday’s top MLB DFS lineups. In the win against the Rangers, Bellinger went 1-4 during a good win against the Rangers.

Bellinger has been one of the Yankees’ better players this season and could have another great game tonight. Fantasy players could see Bellinger have a multi-hit game, including a home run, and win fantasy players cash prizes.

2B/OF Tommy Edman, Arizona Diamondbacks at Los Angeles Dodgers ($4,000 – DraftKings/3,500-Fanduel)

The last player to have for your fantasy lineups is Tommy Edman of the Los Angeles Dodgers in today’s DFS lineups. In the extra-innings win against the Diamondbacks, Edman went 1-2 with an RBI.

Edman has been excellent for the Dodgers this season and could do well again tonight. DFS players could see Edman have a multi-RBI game for the Dodgers and win cash prizes tonight.

May 21st Top MLB DFS Benchwarmers

C Sean Murphy, Atlanta Braves at Washington Nationals (4,300 – DraftKings/2,900-Fanduel)

Sean Murphy is the first player who should be on your top MLB DFS fantasy benches for this Wednesday night. In the loss against the Nationals, Murphy went 0-4 in a brutal loss against their divisional rival.

The Braves catcher has been struggling this week and could have another weak game against the Nationals. Murphy could have another hitless game for the Braves and fantasy players tonight in DFS lineups.

1B Pete Alonso, Baltimore Orioles at Milwaukee Brewers ($5,500 – DraftKings/3,800-Fanduel)

Pete Alonso of the New York Mets is another player who should be on your fantasy benches tonight for DFS lineups. During a brutal shutout loss, Alonso went 0-4 with a strikeout.

Alonso has been struggling for the Mets in the past five games and could have another weak game tonight. Fantasy players could see Alonso have a multi-strikeout game for the Mets tonight to end the road trip.

2B Jake Cronenworth, San Diego Padres at Toronto Blue Jays ($3,900 – DraftKings/3,300-Fanduel)

Jake Cronenworth of the San Diego Padres should be the last player on your top MLB DFS bench for the night. In the shutout loss against the Blue Jays, Cronenworth went 0-3 with a strikeout.

Cronenworth has been sluggish with one hit in his past three games. Fantasy players could see another hitless game from the Padres’ star infielder against the Blue Jays, which could cost DFS players money.

Total Apex Media Stack Of The Day

nl rookie
Apr 18, 2025; Milwaukee, Wisconsin, USA; Milwaukee Brewers third baseman Caleb Durbin (21) gets dunked with Gatorade following the game against the Athletics at American Family Field. Mandatory Credit: Jeff Hanisch-Imagn Images

Wednesday’s top MLB DFS stack should be the Milwaukee Brewers, Brice Turang, Rhys Hoskins, and Jackson Chourio. Milwaukee has been playing good baseball this May, and could have another solid game against the Brewers. Today’s top MLB DFS stack could have a great game against the Orioles’ putrid pitching staff.

In the win against the Orioles, Turang hit a home run at home, and could have another great game. Turang has been a solid hitter for the Orioles and could have another great game against a weak pitching staff. Fantasy players could see a multi-hit game from the Brewers infielder against the Orioles today. 

Another player who could have an excellent game for fantasy players is Hoskins, after a solid game. During last night’s win, Hoskins went 2-4 with a home run and two runs. Fantasy players could see another home run from the veteran slugger in a game against the Orioles. 

The last player for today’s top MLB DFS lineup is Chourio and his emerging abilities as a star player. During last night’s win, Chourio went 1-4 with a walk and a strikeout. Choruio has been struggling this month, but could have a bounce-back game against the Orioles’ weak pitching staff today.

Fantasy players could see a multi-hit game from the Brewers’ star outfielder, including a home run. Today’s top MLB DFS lineups and stacks could help players win cash prizes to end this midweekday slate of baseball games.

More Great Content