Oakland A’s vs Chicago White Sox Odds, Analysis, & Prediction | April 16, 2025

This Oakland A’s vs. Chicago White Sox preview examines Game 2 on Wednesday in the Windy City. In Game 1 on Monday, Oakland rolled 12-3 as the A’s first five batters all scored at least two runs. Game 3 will be played at Rate Field on Thursday. Time to look at the starting pitchers, relevant stats, series trends, and make a pick on this American League game.

A’s vs. White Sox Odds

Oakland Athletics vs. Chicago White Sox

• Game: Oakland Athletics at Chicago White Sox

• Date and Time: Wednesday, April 16, 2025, 7:41 EDT/6:41 CDT/4:41 PDT

• Location: Rate Field (Kentucky Bluegrass), Chicago, Illinois

Key Stats

Oakland Athletics

The Athletics (7-10, 5-3 on the Road) are scheduled to start RHP Osvaldo Bido (1-1, 3.00 ERA, 1.60 WHIP) as the visitors look to take Game 2 of the series. Oakland was 3-3 vs. Chicago last year as both teams struggled through difficult seasons.

In Game 1 on Monday, the A’s exploded for 12 runs as Lawrence Butler (2-4, 2 Runs, RBI). Brent Rooker (2-4, 3 Runs), Tyler Soderstrom (3-5, 3 Runs, 6 RBI, 2 HR), and Shea Langeliers (3-5, 2 Runs, 2 RBI, HR) all made life miserable for White Sox pitchers. The visitors improved to 5-3 on the Road. Oakland is a little better team than it was in 2024, while the White Sox are just as awful. Only the Rockies have a worse record this spring.

A’s Betting Trends

• The A’s are 3-1 in their last four Road games
• Oakland is 5-5 in the last 10 series meetings
• The Under is 6-3-1 in the A’s last 10 games
• Oakland was 10-22 vs. the AL Central Division in 2024
• The A’s were 31-50 on the Road in 2024

Chicago White Sox

The White Sox (4-12, 4-6 at Home) are scheduled to start RHP Jonathan Cannon (0-2, 5.79 ERA, 1.64 WHIP) in an effort to snap a 2-game losing streak. Chicago has the worst record in the Senior Circuit, and the offense has been a big reason why.

Heading into Wednesday’s game, the White Sox ranked No. 29 in four different hitting categories: Batting Average (.200), Runs (53), On Base Percentage (.272), and Slugging Percentage (.300). Cannon has pitched 14.0 IP, allowed 9 ER on 14 Hits with three HRs allowed, so after getting 12 on Monday on the South Side, expect Oakland to score some runs in this one. This team has just 45 wins in its last 178 games overall.

White Sox Betting Trends

• The White Sox are 2-8 in their last 10 games
• Chicago has scored an AL-low 53 Runs
• The Under is 5-2-1 in the last eight White Sox games
• Chicago has scored just seven Runs in its last three games
• The White Sox were 10-22 vs. the AL West Division last season

Prediction

The White Sox are entering auto-fade territory for MLB bettors, much like last season when the team would go on long losing streaks and struggle to score runs. Chicago went an embarrassing 41-121 last season. Oakland has played better away from its new temporary home in Sacramento, and facing the White Sox and Cannon in this spot, should be able to simply outscore the Home team again.

Chicago had a brief respite above the .500 mark after defeating the Angels on Opening Day, but the Pale Hose may not see .500 again until the 2026 MLB Regular Season gets underway and they are 0-0. Sad, but true.

Final Pick

Athletics -158