New Orleans Saints vs. Buffalo Bills Preview, Prediction & Odds | Week 4, 2025

Buffalo
New Orleans Saints (0-3) at Buffalo Bills (3-0)
Game Details: Sunday, September 28, 1:00 p.m. EST
Location: Highmark Stadium, Orchard Park, NY
Where to Watch: CBS

Week 4 Matchup

One team is searching for a pulse, the other for perfection. Sunday’s clash at Highmark Stadium features two franchises heading in completely opposite directions as the winless New Orleans Saints (0-3) travel to face the undefeated Buffalo Bills (3-0). For the Saints, it’s about stopping the bleeding after seven straight losses dating back to last season. For the Bills, it’s about avoiding a trap game against a desperate opponent and proving they deserve their spot atop the AFC.

Betting Odds

Team Spread Money Line Total
New Orleans Saints +15.5+870Over 48.5
Buffalo Bills -15.5-1500Under 48.5

** Odds Subject to Change – Courtesy of FanDuel**

Tale of The Tape

New Orleans SaintsTeam Stats – Avg Per GameBuffalo Bills
15.7Points Per Game34
199.7Passing Yards Per Game257
102.3Rushing Yards Per Game163
30Opponents Points Per Game Allowed23.7
210Opponents Pass Yards Allowed 131.3
103.3Opponents Rush Yards Allowed 156

Key Details

Sep 21, 2025; Seattle, Washington, USA; New Orleans Saints quarterback Spencer Rattler (2) throws the ball during the third quarter against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

New Orleans Saints

The New Orleans Saints are in a tailspin. After two competitive one-score losses to start the year, the wheels came off in a 44-13 drubbing by the Seahawks. First-year coach Kellen Moore is preaching patience, saying, “It’s not a time to panic.” However, with a seven-game losing streak and a cross-country trip to face a rested Bills team, the pressure is mounting. The offense has been its own worst enemy, ranking among the league’s most penalized teams.

Quarterback Spencer Rattler, now 0-9 as a starter, has completed a respectable 67.2% of his passes but hasn’t found the winning formula. Moore has publicly backed his young QB, stating, “I have a lot of confidence in Spencer.”

Buffalo Bills

The Buffalo Bills are 3-0, but they’re the first to admit it hasn’t always been pretty. Quarterback Josh Allen knows fans “want to see fireworks,” but he’s more interested in the final score. “Ultimately, I love winning football games,” Allen said this week. The Bills have been a model of efficiency, with the offense yet to commit a turnover this season. They’ve won with big plays and with methodical, “boring” drives when necessary.

Prediction

This feels like a college football game point spread.  In this case, it is warranted. The Bills will score, and score and score. The Saints will not.

Final Pick

Buffalo Bills  -15.5

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