The 49ers host the Titans in a game that looks competitive early but is likely to see San Francisco pull away as the game progresses. Fantasy managers will want to focus on high-volume players and proven playmakers, while exercising caution with risky or matchup-dependent options.
49ers Starters
QB – Brock Purdy, 49ers
Purdy should be able to carve up the Titans’ secondary and has the potential for multiple touchdowns. He’s a safe start in all fantasy formats, especially in games where San Francisco is expected to dominate.
RB – Christian McCaffrey, 49ers
McCaffrey remains the centerpiece of the 49ers’ offense and is a touchdown threat both on the ground and through the air. He’s a must-start every week.
WR – Juan Jennings, 49ers
Jennings has emerged as the clear WR1 in San Francisco, giving you the best chance to rack up points through the air. He’s a start in all leagues this week.
TE – George Kittle, 49ers
Kittle has been a consistent producer and is set up for another strong week. Expect him to finish among the top-5 tight ends once again.
Quick Hits After Thursday’s Titans Practice – Jim Wyatt via Tennesseetitans.com
RB – Tony Pollard, Titans
After a strong performance last week, Pollard should see heavy touches as Tennessee looks to lean on its ground game. He’s a reliable start in all formats.
Flex – Chimere Dike, Titans
Dike has built solid chemistry with Purdy and could be a sneaky flex play. He’s worth starting in deeper leagues or PPR formats.
NFL’s leader in all-purpose yards? That’s Gators rookie Chimere Dike – Grey Bender via On
Titans Sit
QB – Cam Ward, Titans
Ward has put together some decent games recently, but he faces a tough matchup this week against a 49ers secondary that has been stingy. Sit him in all formats.
Fantasy Takeaway
This is a 49ers-heavy game for fantasy purposes. Purdy, McCaffrey, Jennings, and Kittle are all clear starts, while Titans players like Pollard remain valuable options. Flex plays like Dike could pay off, but Ward is too risky to trust this week.
