If there’s a game this week that screams upset, look no further. The Texans’ defense is playing its best football of the season: fast, physical, and opportunistic. The Colts, meanwhile, have stumbled out of the gate in back-to-back weeks and are dealing with the ripple effects of Daniel Jones’ leg injury. Indy has the offensive talent to hang around, but the momentum clearly favors Houston. Expect a gritty divisional fight with several fantasy storylines riding on how the Colts’ offense holds up.
SIT ’EM

Daniel Jones — QB, Colts
Jones is expected to play, but he’s clearly limited. Against a Texans defense that thrives on closing windows and forcing mistakes, this is not the matchup to roll him out. Sit him unless your roster gives you no alternative.
FLEX / START OPTIONS
Jonathan Taylor — FLEX, Colts
Taylor has had a string of slow weeks, but the volume is still there. The offense may lean on him more with Jones banged up, giving Taylor solid FLEX value with RB2 upside if he finds the end zone.
Michael Pittman Jr. — WR, Colts
This one will reveal everything early. Pittman’s performance depends heavily on how mobile and effective Daniel Jones can be. Start him with cautious optimism; his talent gives him a safe floor, but the QB concerns cap his ceiling.
Tyler Warren — TE, Colts (Start)
Warren remains a top-10 fantasy tight end and a reliable target near the goal line. Even with Jones limited, Warren’s role is secure. Strong TE start in all formats.
Josh Downs — FLEX, Colts
Downs has an undeniable nose for the end zone and continues to pop up in big moments. With Jones limited, he may see more short-area targets. A quality FLEX, especially in PPR.
Sit: Alec Pierce — WR, Colts
Someone is going to feel the squeeze from Jones’ limited mobility and the Texans’ tight coverage, and Pierce is the likeliest casualty. His deep-shot role struggles in this matchup. Bench him.
TEXANS START ’EM
CJ Stroud — QB, Texans (Start)
All Stroud needs to do is step in and pick up where Davis Mills left off. The Texans’ offense is humming, and the matchup favors Houston. Stroud should deliver efficient QB1 numbers.
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Nico Collins — WR, Texans (Start)
Stroud and Collins should quickly reestablish their connection. Collins’ physicality and Stroud’s accuracy make him a weekly starter, and this matchup strengthens his outlook. Strong WR2 with WR1 upside.
Christian Kirk — FLEX, Texans
Kirk has locked himself into the WR2 role and continues producing with steady volume. Against a Colts defense that has shown cracks, he’s a solid FLEX with PPR juice.
Jayden Higgins — FLEX, Texans
At this point, he’s more than a sleeper. Higgins’ touchdown last week only boosted his value, and he’s clearly earning the trust of the coaching staff. High-upside FLEX, especially in deeper leagues.
Dalton Schultz — TE, Texans (Sit)
Too many mouths to feed in Houston’s passing attack, and Schultz has been squeezed out of consistent usage. Not worth the gamble this week. Sit him.
FINAL TAKEAWAY
This matchup sets up perfectly for a Texans upset. Houston’s defense is surging at just the right time, and the Colts’ slow starts—and Daniel Jones’ injury—could spell trouble. Fantasy managers should prioritize Texans playmakers, cautiously lean on the Colts’ top options, and avoid the landmines created by the offensive limitations.
