Indianapolis Colts vs. Atlanta Falcons Start Em Sit Em Week 10 2025 Fantasy Football Guide

Drake London falcons

The Indianapolis Colts have quietly become one of fantasy football’s most reliable teams. Each week, five players from their offense seem to produce starter-worthy numbers, and now they’ve bolstered their defense with a major trade, adding balance to a roster that’s surging at the right time.

Drake London vs. Sauce Gardner is Sure to be a Show

Meanwhile, the Atlanta Falcons are slipping in the NFC South standings, turning every remaining game into a must-win scenario. The offense has flashed behind Michael Penix Jr. and Bijan Robinson, but consistency remains the key.

Let’s break down which players to trust and which to bench in this cross-conference matchup.

Fantasy Quick Start Table

PlayerTeamPosMatchup OutlookStart Meter (1–10)Fantasy Take
Daniel JonesINDQBvs ATL🔥 8.5Exploitable matchup; expect 2+ TDs
Jonathan TaylorINDRBvs ATL💪 8Bounce-back week, TD upside
Michael Pittman Jr.INDWRvs ATL🔥 980+ yards & score likely
Tyler WarrenINDTEvs ATL💪 7TE2 with bounce-back potential
Alec PierceINDFLEX (WR)vs ATL⚡ 7Deep threat with 100-yard upside
Josh DownsINDFLEX (WR)vs ATL💪 6.5Lower yardage, red-zone weapon
Michael Penix Jr.ATLQB@ IND💪 7.5Steady streamer; 1–2 TD potential
Bijan RobinsonATLRB@ IND🔥 8.5Favorable matchup vs run defense
Drake LondonATLWR@ IND💪 7.5Coming off breakout, strong WR2 play
Kyle PittsATLTE@ IND⚡ 7Bounce-back candidate
Darnell MooneyATLWR@ IND❌ 3Not enough volume, sit him

🔥 Colts Starts

Detroit Lions cornerback Amik Robertson (21) tackles Indianapolis Colts wide receiver Michael Pittman Jr. (11) during the first half at Lucas Oil Stadium in Indianapolis, Ind. on Sunday, Nov. 24, 2024.

Daniel Jones, QB, Colts

Jones is in a dream spot this week against a Falcons defense that’s allowed 20+ fantasy points to opposing QBs in consecutive weeks. With his mobility and red-zone usage, expect 2–3 total touchdowns and a strong fantasy day.

Jonathan Taylor, RB, Colts

Taylor’s coming off a quiet outing, but this is the kind of bounce-back spot elite backs love. The Falcons have struggled to contain physical runners, and Taylor should find the end zone while pushing for 100 total yards.

Michael Pittman Jr., WR, Colts

Pittman’s been a target hog, and his recent production has been top-10 WR caliber. Expect 8+ targets, around 80 yards, and a likely touchdown. He’s a must-start in all formats.

Tyler Warren, TE, Colts

After a down game, Warren is a sneaky bounce-back play. The Falcons have allowed multiple tight ends to post double-digit fantasy weeks this season. Consider him a TE2 with TE1 upside.

antasy Football Week 10 Waiver Wire Pickups: Alec Pierce among top players to target – Justin Boone via ca.sports.yahoo.com

Alec Pierce, FLEX (WR), Colts

Pierce’s deep-ball role makes him volatile, but when he hits, he hits big, as shown by last week’s 100+ yard performance. He’s a solid FLEX in 12+ team leagues.

💪 Josh Downs, FLEX (WR), Colts

Downs doesn’t rack up massive yardage totals, but he’s developed into a trusted red-zone target. A solid FLEX option, especially if you’re navigating bye-week chaos.

💥 Falcons Starts

Michael Penix Jr., QB, Falcons

Penix continues to prove he can hang at the NFL level. He threw three touchdowns last week and faces a Colts defense that can give up chunk plays through the air. Expect 250+ yards and at least one score.

Bijan Robinson, RB, Falcons

Robinson’s numbers have dipped recently, but the Colts’ run defense has shown cracks. Expect Arthur Smith to re-commit to his star back. Bijan’s a locked-in RB1 this week with big-play potential.

Drake London’s true thoughts on Christian Gonzalez after three-TD performance – Jordy mcElroy via patriots.usatoday.com

Drake London, WR, Falcons

London exploded last week and now faces a tougher matchup, but he’s too involved to bench. The Colts’ secondary gives up chunk plays, and London’s red-zone role keeps him in the WR2 conversation.

💪 Kyle Pitts, TE, Falcons

Pitts disappointed last week, but his usage remains encouraging. The Colts have allowed tight ends to score 20+ fantasy points multiple times this year. He’s a solid start in standard and PPR leagues.

🚫 Sit ’Em

Darnell Mooney, WR, Falcons

Mooney remains inconsistent and sits behind London and Pitts in the target pecking order. With limited looks and no touchdown reliability, he’s best left on your bench this week.

📊 Game Prediction

Colts 27, Falcons 23

Expect a tight, fantasy-friendly game with both offenses moving the ball effectively.

The Colts’ offense stays balanced with Jones, Taylor, and Pittman leading the way, while Bijan Robinson and Drake London keep the Falcons competitive.

Fantasy managers can fire up their Colts with confidence; this team remains one of the most fantasy-friendly units in football.

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