Indianapolis Colts vs. Kansas City Chiefs Start Em Sit Em WEEK 12 2025 Fantasy Football

chiefs

The Chiefs are stumbling, and pressure is rising as they fight to avoid a late-season collapse. Meanwhile, the Colts are coming off a bye, rested, confident, and hunting a statement win that would push them to a stunning 9–2. This matchup has major fantasy playoff implications and plenty of fantasy volatility on both sides.

Below are your Week 12 ratings + breakdown.

START ’EM

Colts
Oct 26, 2025; Indianapolis, Indiana, USA; Indianapolis Colts running back Jonathan Taylor (28) celebrates after the game against the Tennessee Titans at Lucas Oil Stadium. Mandatory Credit: Robert Goddin-Imagn Images

Daniel Jones — QB, Colts

Start Rating: (4/5)

Projection contingent on him playing

Monitor his calf injury, but if active, Jones should clear 230 yards and a TD, with real rushing upside against a Chiefs defense that has cracked in recent weeks.

Jonathan Taylor — RB, Colts

Start Rating: (5/5)

KC has struggled against physical run games all year. Taylor is fresh off a bye and should feast between the tackles with scoring upside.

Michael Pittman Jr — WR, Colts

Start Rating: (4/5)

WR1 volume + favorable slot perimeter matchups. Should find plenty of work similar to what Denver WRs did vs KC.

Alec Pierce — WR, Colts

Start Rating: (3/5)

Strong Flex / Deep-league starter. Production rising weekly, downfield shots + red zone usage growing.

Tyler Warren — TE, Colts

Start Rating: (4/5)

Quietl,y one of the best values at TE this season. He can absolutely repeat what Kincaid did to Kansas City.

Sleeper – Josh Downs — WR, Colts

Start Rating: (2.5/5)

Red-zone chemistry + third-option reliability. Great plug-and-play in bye/injury trouble.

Josh Downs and the art of moving the chains – Andrew Ariz via Stampede Blue

Kansas City Chiefs

Patrick Mahomes — QB

Start Rating: (4.5/5)

Backs against the wall. Expect volume + multiple scores in desperation mode.

Travis Kelce — TE

Start Rating: (5/5)

It’s crunch time, and Mahomes trusts nobody more. Red zone TD feels very possible.

Kareem Hunt — RB

Start Rating: (3/5)

More consistent than Pacheco with him out, so Hunt is more active in the passing game in those games. Strong FLEX.

‘It’s a One-Game Season’ – Chiefs vs. Colts Preview w/ Kareem Hunt | Defending the Kingdom via chiefs.com

Rashee Rice — WR

Start Rating: (2.5/5)

Tough matchup. Low-end flex only.

Xavier Worthy — WR (Deep Leagues)

Start Rating: (2/5)

Deep multi-flex consideration. May roam free while Rice is shadowed.

🚫 SIT ’EM

Hollywood Brown — WR, Chiefs

Sit Confidence: High

This matchup does not favor splash-dependent receivers. Bench with confidence.

Chiefs D/ST (Conditional)

Sit if Daniel Jones plays

Start only if he’s ruled OUT

They’ve been unreliable & exposed vs efficient offenses.

FINAL TAKEAWAY

This matchup is a crossroads game:

Colts = momentum, health, fresh legs

Chiefs = desperation, pressure, uncertainty

Expect:

• Taylor dominating the clock

• Mahomes forced into volume mode

• Pittman + Kelce anchoring passing attacks

• Pierce & Hunt turning into pivotal FLEX plays

If Jones suits up, the Colts control this game.

If not, this becomes chaos.

Either way…this one will shape fantasy playoff fates.

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