Indianapolis Colts vs. Los Angeles Chargers Start ’Em, Sit ’Em Week 7 2925 Fantasy Guide

los angeles chargers

This matchup features two young quarterbacks leading their teams through a wide-open AFC playoff race. Both the Colts and Chargers are in striking distance of postseason contention, and this game could have major implications down the stretch. Expect a fast-paced, high-scoring affair with plenty of fantasy fireworks on both sides.

🏈 Quick Start/Sit Table

PlayerTeamStatusFantasy Note
🐎 Daniel JonesColts✅ StartGreat matchup vs. defense allowing 20+ pts per game
🐎 Jonathan TaylorColts✅ StartPrime spot for a breakout; Chargers can’t stop the run
🐎 Michael Pittman Jr.Colts✅ StartTarget magnet; due for a bounce-back and possible TD
🐎 Tyler WarrenColts✅ StartRookie TE on a hot streak; solid red-zone target
🐎 Josh DownsColts💪 FlexReliable WR2 in deep leagues; volume keeps him viable
⚡ Justin HerbertChargers✅ StartStrong QB1 option vs. a defense that gives up chunk plays
⚡ Konami VidalChargers💪 Flex/StartTook over the backfield; 120+ yds last week, momentum rolling
⚡ Ladd McConkeyChargers💪 FlexBack-to-back TD games; trending upward in usage
⚡ Quentin JohnstonChargers❌ SitBattling injury and inconsistent; keep benched for now

STARTS

Daniel Jones – QB, Colts

Jones draws a favorable matchup against a Chargers defense that has been generous through the air, allowing over 20 fantasy points per game to opposing quarterbacks. With time to throw and his mobility as a bonus, Jones is a safe start with upside for multiple scores.

Jonathan Taylor – RB, Colts

The matchup screams “breakout game.” The Chargers’ front has struggled to contain running backs in recent weeks, and Taylor’s combination of burst and vision should lead to a big day. Expect 100+ total yards and a touchdown.

Michael Pittman Jr. – WR, Colts

Pittman may have had a quieter week recently, but his target share remains elite. As Jones’ top option, Pittman is always a threat in the red zone. Expect him to rebound in a matchup that favors big outside receivers.

Tyler Warren – TE, Colts

The rookie tight end continues to produce in key moments, finding the end zone again last week. With defenses starting to key on Pittman, Warren should find plenty of room to operate in the seams. A strong TE1 streamer this week.

Anytime touchdown scorer picks: Tyler Warren among best Week 7 player props for Colts vs. Chargers – Brandon Gustaffson via cbssports.com

💪 FLEX PLAYS

Josh Downs – WR, Colts

Downs continues to be a reliable short-yardage and possession option. His chemistry with Jones makes him a safe flex play in deeper formats, especially in PPR leagues.

Kimani Vidal – RB, Chargers

Vidal exploded for over 120 yards last week and looked like the clear lead back in this offense. The Colts have been middle-of-the-pack against the run, giving Vidal a strong shot at another productive outing.

Ladd McConkey – WR, Chargers

McConkey has come to life over the past two weeks, scoring in back-to-back games. His speed and versatility give Herbert a reliable second option behind the top wideout. He’s a sneaky flex play with touchdown upside.

Ladd McConkey to the rescue, 4 other things to know about Colts vs. Chargers -Russell Baxter vis SI.com

START

Justin Herbert – QB, Chargers

Herbert continues to look sharp and efficient, spreading the ball around with confidence. The Colts defense has given up points to nearly every QB they’ve faced, making Herbert a locked-in QB1 this week. Expect 275+ yards and multiple scores.

SIT

Quentin Johnston – WR, Chargers

Johnston’s inconsistency and injury status make him too risky to trust this week. Until he returns healthy and reclaims a steady target share, keep him on the bench.

🔮 Fantasy Outlook Summary

Colts
Oct 5, 2025; Indianapolis, Indiana, USA; Indianapolis Colts quarterback Daniel Jones (17) walks off the field after their win against the Las Vegas Raiders at Lucas Oil Stadium. Mandatory Credit: Trevor Ruszkowski-Imagn Images

This one could easily turn into a shootout. Daniel Jones and Justin Herbert are both trending upward, while Jonathan Taylor and Kimani Vidal headline a matchup full of big-play potential. Look for Pittman and McConkey to make key contributions through the air, and keep an eye on Tyler Warren, who’s emerging as one of fantasy’s most reliable rookie tight ends.

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