The Colts head into this matchup sitting at 4-1 and firmly in control of the AFC South. Daniel Jones has been lights out, ranking 3rd in the NFL with 1,290 passing yards while posting six touchdowns to only two interceptions.
The Cardinals, on the other hand, are reeling after a narrow loss to the Titans and desperately need to find consistency. With Kyler Murray leading the charge and Marvin Harrison Jr. emerging as a top weapon, Arizona will try to keep pace with one of the AFC’s hottest teams.
This game has the potential to be a fantasy goldmine: loaded with offensive firepower on both sides. Let’s dive into who you should start, who you should sit, and who might just surprise you this week.
🔥 Start ‘Em
Daniel Jones – QB, Colts
Jones is red-hot right now. His dual-threat ability continues to make him a fantasy stud, and he’s averaging over 250 yards per game. Expect multiple touchdowns, two through the air or one on the ground, against a banged-up Cardinals defense.
Start Meter: 🔥🔥🔥🔥🔥
Jonathan Taylor – RB, Colts
JT looks like the throwback fantasy workhorse reminiscent of LaDainian Tomlinson and Larry Johnson. He’s running with confidence behind one of the best O-lines in football. Expect 100+ yards and a score.
Start Meter: 🔥🔥🔥🔥🔥
Michael Pittman Jr. – WR, Colts
Arizona’s secondary has been decimated by injuries, which opens the door for Pittman to feast. Expect double-digit targets and a strong WR1 showing.
Start Meter: 🔥🔥🔥🔥
Indianapolis Colts’ Tyler Warren rewriting rookie history at the tight end position -pff.com
Tyler Warren – TE, Colts
The rookie tight end continues to impress and looks like a future top-10 fantasy TE. With Jones spreading the ball around, Warren has become a red-zone favorite.
Start Meter: 🔥🔥🔥
🔥 Start ‘Em (Cardinals)
Kyler Murray – QB, Cardinals
Murray is finally in rhythm, connecting with Harrison Jr. and showing improved pocket presence. Expect 250+ total yards and multiple touchdowns.
Start Meter: 🔥🔥🔥🔥
Michael Carter – RB, Cardinals
Carter looked like the true RB1 last week and should maintain that role. His versatility as a pass-catcher gives him a strong fantasy floor.
Start Meter: 🔥🔥🔥
Week 6 fantasy football TE rankings: Best starts at tight end – Steve Gardner via usatoday.com
Trey McBride – TE, Cardinals
McBride’s 30 receptions and 9 yards per catch average speak to his consistency. The touchdowns will come soon, possibly this week in a high-scoring game.
Start Meter: 🔥🔥🔥
💪 Marvin Harrison Jr. – WR, Cardinals
The rookie continues to deliver. Coming off a 4-catch, 94-yard performance, MHJ should again top 70 yards and find the end zone.
Start Meter: 🔥🔥🔥🔥
💪 Emari Demercado – RB/Flex, Cardinals
Demercado was one play away from a huge game last week (and that fumble was questionable at best). He’s an intriguing deep flex play with upside in PPR formats.
Start Meter: 🔥🔥
🚫 Sit ‘Em
Cardinals Defense
Facing a red-hot Colts offense led by Daniel Jones and Jonathan Taylor is a recipe for trouble. The Colts should put up 24+ points with ease, leaving the Arizona D as a definite sit this week.
Sit Meter: 💀💀💀💀💀
🌙 Sleeper of the Week:
Josh Downs – WR, Colts
Downs has quietly carved out a role as the Colts’ chain-moving slot receiver. If Arizona sells out to stop Pittman, Downs could slip through for 5–6 catches and a score. A sneaky flex option in deeper leagues.
📊 Projected Fantasy Stats
| Player | Pos | Projection |
| Daniel Jones | QB | 285 YDS, 2 TD, 1 RUSH TD |
| Jonathan Taylor | RB | 108 YDS, 1 TD, 3 REC, 22 YDS |
| Michael Pittman Jr. | WR | 7 REC, 91 YDS, 1 TD |
| Tyler Warren | TE | 5 REC, 48 YDS, 1 TD |
| Kyler Murray | QB | 265 YDS, 2 TD, 35 RUSH YDS |
| Michael Carter | RB | 72 YDS, 4 REC, 38 YDS |
| Trey McBride | TE | 6 REC, 64 YDS |
| Marvin Harrison Jr. | WR | 5 REC, 78 YDS, 1 TD |
| Emari Demercado | RB | 55 TOTAL YDS |
| Josh Downs | WR | 5 REC, 40 YDS, |
🏁 Wrap-Up
This matchup has shootout potential, and fantasy managers should load up on offensive players from both sides. The Colts’ balanced attack looks too strong for Arizona’s defense to contain, but expect Kyler Murray and Marvin Harrison Jr. to keep things interesting. Fire up your Colts and Cardinals skill players: this one should light up the fantasy scoreboard.
