Buffalo Bills at Cleveland Browns Preview, Prediction & Odds | Week 16, 2025

survivor pick
Buffalo Bills (10-4) at Cleveland Browns (3-11)
Game Details: Sunday, December 21, 1:00 p.m. EST
Location: Huntington Bank Field, Cleveland, OH
Where to Watch: CBS

Week 16 Matchup

With the AFC playoff picture nearly clear and teams trying to clinch a playoff spot, the Buffalo Bills are looking to clinch a spot today against the Cleveland Browns. The Bills are having another solid season, and bettors could have an easy win with them facing a weak Browns team. Bettors could have an easy win for today’s game with the Buffalo Bills preparing for another run in the playoffs, while the Cleveland Browns are preparing for another potential rebuild next year.

Betting Odds

Team Spread Money Line Total
Buffalo Bills-10.5-670Over 41.5
Cleveland Browns +10.5+480Under 41.5

** Odds Subject to Change – Courtesy of FanDuel**

Tale of The Tape

Buffalo BillsTeam Stats – Avg Per GameCleveland Browns
29.4Points Per Game16.1
222.7Passing Yards Per Game172.0
158.5Rushing Yards Per Game92.4
23.1Opponents Points Per Game Allowed23.7
169.5Opponents Pass Yards Allowed 169.0
143.1Opponents Rush Yards Allowed 110.1

Statistics from various online sources, courtesy of ESPN and FOX Sports

Key Details

browns
Sep 14, 2025; Baltimore, Maryland, USA; Cleveland Browns running back Quinshon Judkins (10) runs the ball against Baltimore Ravens linebacker Roquan Smith (0) during the fourth quarter at M&T Bank Stadium. Mandatory Credit: Peter Casey-Imagn Images

Buffalo Bills

After one of their best wins against their hated rival, the Buffalo Bills are looking to keep the momentum against the Browns on Sunday. Buffalo’s offense has been having another solid season, with Josh Allen competing for another MVP, with strong offensive numbers. Buffalo’s run game, while solid with James Cook, could have a great game against the Browns and their regressing defense. 

The Buffalo Bills flaw that could hurt bettors chances is the defense, with them suffering injuries and regression. While the defense is flawed, they could do well against the Browns, whose offense has been regressing with weak quarterback play. 

Cleveland Browns

The Cleveland Browns this season have been having another nightmare season, with the potential of firing their coaching staff. Cleveland has been playing poorly, with the roster being in chaos, and Shedeur Sanders having a weak rookie season for the team. 

The Browns‘ run game has also been weak, with around 98 rushing yards a game, due to injuries and inconsistency for the team. There is also the Browns defense, which has great players, but the game planning has been a nightmare and could collapse again.

Prediction

The Buffalo Bills are looking to have a Super Bowl run, and the Cleveland Browns are having a nightmare season, so it’s easy to pick the Bills to cover. Buffalo has been playing well, even with a messy defense, and could have a strong game against the Browns. With the Browns’ offense being dysfunctional, the Bills’ defense could do well and cover the score for bettors. The NFL season is ending, and bettors could win a lot of money, with the Buffalo Bills winning and covering the line, along with the under for the team. 

Final Pick

Buffalo Bills  -10.5

Under 41.5

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