Buffalo Bills vs. Miami Dolphins Start Em Sit Em Week 10 2025 Fantasy Football Guide

Bills

The Buffalo Bills are once again proving they own the regular-season rivalry against Kansas City, taking down the Chiefs in another statement win. This week, they face a struggling Miami Dolphins team that’s rapidly sinking in the AFC standings. Buffalo’s offense looks poised for a fantasy feast, while Miami’s stars continue to fight for relevance amidst inconsistency and injuries.

Fantasy Quick Start Table

PlayerTeamPosMatchup OutlookStart Meter (1–10)Fantasy Take
Josh AllenBUFQB@ MIA🔥 10Dual-threat dominance; 3 TD potential
James CookBUFRB@ MIA💪 8.5Dolphins can’t stop the run; 80+ yards & score
Khalil ShakirBUFWR@ MIA💪 8Allen’s favorite target; trending up
Dalton KincaidBUFTE@ MIA💪 7.5Reliable TE1 with consistent usage
Bills DefenseBUFDEF@ MIA🔒 9Facing a stagnant offense, turnover upside
Devon AchaneMIARBvs BUF💪 7Explosive, but limited volume; solid flex
Jaylen WaddleMIAWRvs BUF💪 6.5Still producing despite QB struggles
Tua TagovailoaMIAQBvs BUF⚠️ 5Volume there, efficiency isn’t
Tyreek HillMIAWRvs BUF⚠️ 5Always a threat, but cooled off lately
Dolphins DefenseMIADEFvs BUF❌ 2Facing an elite offense — stay far away

🔥Starts

Josh Allen, QB, Bills

When Allen faces an overmatched defense, fantasy managers feast. Expect two passing touchdowns and one rushing score, with plenty of yardage through the air. Miami has allowed multiple QB1 finishes in consecutive weeks. Allen is a must-start and could finish as the overall QB1 this week.

James Cook, RB, Bills

Cook continues to produce efficiently, and the Dolphins’ run defense is among the league’s worst. With Buffalo likely playing from ahead, expect 80+ total yards and a touchdown. A top-12 RB finish is within reach. *Update: Cook didn’t practice on 11/5, Wednesday, so monitor this situation. If he is out, Ray Davis/ Ty Johnson could be flex options.

💪 Khalil Shakir, WR, Bills

Shakir’s role as Allen’s most trusted wideout has solidified. His route volume and target share have spiked, and his after-catch ability makes him a PPR gem. Fire him up confidently as a WR2/FLEX.

Buffalo Dan Orlovsky: Reasons For Optimism, Kincaid A Matchup Nightmare, Young Secondary Shines via buffalo bills.com

Dalton Kincaid, TE, Bills

Kincaid continues to separate himself from Dawson Knox with a larger target share and more red-zone involvement. The Dolphins have struggled against tight ends, expect 5+ catches and a shot at a score.

Buffalo Defense/Special Teams

This unit thrives on pressure and takeaways, and they get an offense that’s gone stale. With Miami’s offensive line banged up and Tua turning the ball over, the Bills’ defense is a top-5 play this week.

💪 Flex Plays & Sleepers

miami dolphins
Sep 22, 2024; Seattle, Washington, USA; Miami Dolphins running back DeVon Achane (28) rushes against the Seattle Seahawks during the first quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

💪 De’Von Achane, RB, Dolphins

Achane’s burst keeps him fantasy relevant even when the rest of the offense is sputtering. Though volume is a concern, he can flip your matchup with one big play. Treat him as a high-upside FLEX option.

💪 Jaylen Waddle, WR, Dolphins

Waddle remains one of the few steady contributors for Miami. While Tua’s inconsistency limits his ceiling, his target share and red-zone looks keep him viable. A safe WR3/FLEX play in PPR leagues.

Massive price tag pushed Steelers away from Jaylen Waddle trade – Nick Farabaugh via pensive.com

🚫 Sit ’Em

Miami Defense

There’s not much to analyze here. Buffalo’s offense is rolling, and the Dolphins’ defense is reeling. Facing Josh Allen, James Cook, and a top-5 scoring attack, this is an automatic “Do Not Start”. Expect 30+ points allowed and minimal turnover opportunities.

⚠️ Tua Tagovailoa, QB, Dolphins

Tua’s fantasy value has taken a major hit. He’s averaging fewer than 200 yards per game over his last three and has been turnover-prone under pressure. Against Buffalo’s opportunistic defense, he’s best left on your bench unless you’re desperate.

📊 Game Prediction

Bills 34, Dolphins 17

Buffalo rolls to another decisive win behind Josh Allen’s total dominance and a balanced offensive attack. Expect Cook and Shakir to shine in fantasy lineups, while Miami’s offense sputters again outside of a few big plays from Achane and Waddle.

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