San Francisco 49ers at Seattle Seahawks Preview, Prediction & Odds | Divisonal Round 2025

san francisco 49ers
San Francisco 49ers (12-5) at Seattle Seahawks (14-3)
Game Details: Saturday, November 2, x p.m. EST
Location: Lumen Field Seattle, WA
Where to Watch: FOX

NFC Divisional Matchup

With a trip to the championship game on the line, the San Francisco 49ers take on the Seattle Seahawks in another game of their heated rivalry. The Niners have been having a strong run, even with the injuries they have, against a Seahawks who have been rested. Bettors could have a great game with two rivals that don’t like each othe,r and have another classic game for fans.

Betting Odds

Team Spread Money Line Total
San Francisco 49ers+7+270Over 44.5
Seattle Seahawks-7-330Under 44.5

** Odds Subject to Change – Courtesy of FanDuel**

Tale of The Tape

San Francisco 49ersTeam Stats – Avg Per GameSeattle Seahawks
23.0Points Per Game28.4
286.0Passing Yards Per Game228.1
75.0Rushing Yards Per Game123.3
19.0Opponents Points Per Game Allowed17.2
167.0Opponents Pass Yards Allowed 193.9
140.0Opponents Rush Yards Allowed 91.9

Statistics from various online sources, courtesy of ESPN and FOX Sports

Key Details

Seahawks top nfl dfs lineup
Seattle Seahawks quarterback Sam Darnold (14) looks to pass during the second quarter of an NFL football matchup, Sunday, Oct. 12, 2025, at EverBank Stadium in Jacksonville, Fla. The Seahawks defeated the Jaguars 20-12.

San Francisco 49ers

After a strong win against the Eagles, the San Francisco 49ers are hoping to keep their momentum against the Seattle Seahawks. The Niners offense against the Eagles was a great performance by Brock Purdy and Demarcus Robinson against the Eagles. Purdy had an amazing performance against the Eagles, but has been playing poorly against the Seahawks. In their loss against them in week 18, Purdy had no touchdowns, two sacks, and an interception.

There is also the Seahawks defense being an elite unit that could pressure Purdy again, along with stopping the run game of Christian McCaffrey. While the Niners’ offense could have a chance against the Seahawks, even with their weakness in the offense, the defense could have a rough game against the Seahawks offense. San Francisco allowed 300 yards per game with their secondary and linebacker core being hurt, and the defensive front being weak and not rushing and pressuring the quarterback.  

Seattle Seahawks

While the San Francisco 49ers are heading into Lumen Field coming off a close win, the Seattle Seahawks could have a strong game against the Niners. Seattle has been having a great season after missing the playoffs. The Seahawks have been playing well, with their defense being in elite form, with Devon Witherspoon having another strong season for the Seahawks’ secondary.

Seattle’s defense has been playing against the Niners in their season series and could have another strong game against them in the divisional round. Seattle’s offense has also been playing well with Sam Darnold having a strong regular season, despite flaws with turnovers and the Seahawks weak run game. Seattle could have a great game against the Niners, and it could take them to another Super Bowl run in their franchise.

Prediction

While the San Francisco 49ers run is nice, their injuries could prove too much for bettors to trust, and the Seahawks have rest, so the Seahawks could win this divisional game. The Niners’ offense has been playing well, and losing Kittle won’t damage it, but the defense has been destroyed with injuries, and Seattle could exploit it as they did in week 18.

Seattle has also beaten the Niners in a blowout at Santa Clara and could have another great game against their defense from Darnold, who could have a great game to start their playoff run. Bettors could easily see the Seahawks blow out the Niners in an ugly game, and see them cover the line and the under in a potential shutout win.

Final Pick

Seattle Seahawks  -7

Under 44.5

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