Buffalo Bills vs. New England Patriots Preview, Prediction & Odds | Week 15, 2025

buffalo bills parlay
Buffalo Bills (9-4) at New England Patriots (11-2)
Game Details: Sunday, December 14, 1:00 p.m. EST
Location: Gillette Stadium, Foxborough, MA
Where to Watch: CBS

Week 15 Matchup

With the AFC playoff picture heading to its climax soon, bettors could win cash in this AFC East rivalry between the Buffalo Bills and the New England Patriots. The AFC East is getting close to being clinched for the Patriots, who are 11-2 and have a ten-game winning streak going against a Bills team who are 9-4, still clinging to hope for another divisional title.

Betting Odds

Team Spread Money Line Total
Buffalo Bills-1.5-118Over 49.5
New England Patriots +1.5+100Under 49.5

** Odds Subject to Change – Courtesy of FanDuel**

Tale of The Tape

Buffalo BillsTeam Stats – Avg Per GameNew England Patriots
28.9Points Per Game27.0
225.9Passing Yards Per Game249.7
157.8Rushing Yards Per Game112.9
22.5Opponents Points Per Game Allowed18.5
171.8Opponents Pass Yards Allowed 206.9
135.2Opponents Rush Yards Allowed 89.5

Statistics from various online sources, courtesy of ESPN and FOX Sports

Key Details

patriots
Dec 22, 2024; Orchard Park, New York, USA; New England Patriots quarterback Drake Maye (10) throws a pass under pressure from Buffalo Bills safety Cole Bishop (24) and linebacker Dorian Williams (42) in the fourth quarter at Highmark Stadium. Mandatory Credit: Mark Konezny-Imagn Images

Buffalo Bills

After one of their best wins against the Bengals, the Buffalo Bills are looking to ride their momentum against the Patriots at Foxborough. The Bills’ offense, while shaky, has Josh Allen, who is still playing well and could have another strong game with James Cook helping out. Buffalo’s offense has been ranked in the middle tiers, but could still pack a punch against the Patriots. A concern for the Bills is the defense, with injuries plaguing the team of linebackers and interior defenders. Buffalo’s chances are slim, but it could impact the game for bettors on Sunday. 

New England Patriots

After a couple of years in the NFL basement, the New England Patriots are back in the forefront of the NFL playoff picture. The roster led by Drake Maye, who is emerging as a superstar, has been slinging the ball to emerging receivers. New England’s defense is also showing great improvement from last year, being a top-tier defense with Mike Vrabel coaching them. The Patriots have been improving and could have a strong showing against the Bills in a crucial game for the AFC East.

Prediction

The house in Vegas believes this could be a close game, and it will be for the Patriots’ favor due to their younger roster. New England has been on a hot streak and could deliver another strong game from Maye against a weak Bills defense. While the Buffalo Bills have experience in difficult games, the Patriots’ young roster could outmaneuver them on offense and defense. Bettors should take the Patriots this Sunday due to their roster talent and the fact that they are facing the Bills’ injured defense and taking the cover.

Final Pick

New England Patriots -1.5

Under 49.5

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