Our Chicago White Sox vs. Cleveland Guardians prediction sees the Chicago White Sox (2-9, fifth in AL Central) go on the road to take on the Cleveland Guardians (5-6, third in AL Central) in an AL Central matchup on Thursday afternoon to wrap up the three-game series. The Guardians are looking for the sweep after they won 1-0 on Tuesday and 3-2 on Wednesday. The White Sox are sending young righty Jonathan Cannon to the bump while the Guardians counter with young right-hander Gavin Williams.
Chicago White Sox vs. Cleveland Guardians Odds
| Team | Spread | Total | Money Line |
| Chicago White Sox | +1.5 (-110) | Over 7.5 (+105) | +190 |
| Cleveland Guardians | -1.5 (-110) | Under 7.5 (-130) | -250 |
| **Odds Subject to Change** |
Chicago White Sox vs. Cleveland Guardians Match Details
- Fixture:Â Chicago White Sox vs. Cleveland Guardians
- Date and Time:Â Thursday, April 10, 2025 at 1:10 pm ET
- Location:Â Progressive Field in Cleveland, OH
Key Stats
Chicago White Sox
The Chicago White Sox are coming off a 3-2 road loss against the Cleveland Guardians in the middle game of the series. The lineup was 8-for-34 with six walks and 12 strikeouts. Austin Slater’s double was the only extra-base hit for the team on the day while Miguel Vargas stole a base. Chicago was 3-for-12 with runners in scoring position and left 11 men on base. Sean Burke struggled to give much length as he pitched three innings in the game and allowed three runs in a losing effort.
Young right-hander Jonathan Cannon is going to be starting in this game for the Chicago White Sox and is 0-1 with a 3.12 ERA and a 1.50 WHIP in 8.2 innings so far. He has struggled with command as he has six walks and a pair of hit by pitches thus far. Cannon faced Cleveland once last season and lost that start as he pitched 5.1 innings and gave up three runs on seven hits with one walk and four strikeouts.Â
Cleveland Guardians
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The Cleveland Guardians are looking to hit the baseball more consistently as they are coming off a 3-2 home win over the Chicago White Sox. The Guardians finished 3-for-26 with seven walks and eight strikeouts in the game. Carlos Santana hit his second homer of the season and the team was aggressive on the basepaths with Austin Hedges and Steven Kwan stealing a base while Nolan Jones was caught stealing. Cleveland was just 1-for-7 with runners in scoring position while leaving seven men on base. Logan Allen failed to pitch five innings and allowed an unearned run while the bullpen dominated. Â
Young righty Gavin Williams is going to be toeing the slab for the Cleveland Guardians in this game and he is 0-0 with a 4.50 ERA and a 1.63 WHIP in 8.0 innings of work. Hitters have swung the bat well against him with a .273 batting average against Williams. He pitched once against the White Sox and lost as he allowed five runs on seven hits with two walks and two strikeouts in four innings of work. Â
Prediction
These teams have scored a combined six runs in the first two games of the series, but the over is the better option for this game. Both Jonathan Cannon and Gavin Williams have struggled a bit with their command so these offenses should be able to take advantage. The pitching staffs have allowed home runs as the Guardians are tied for 10th with 14 homers allowed while the White Sox are tied for 20th with 11 homers given up. All in all, go with over 7.5 runs to be scored in the series finale.
