Buffalo Bills at Denver Broncos Preview, Prediction & Odds | Divisonal Round 2025

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Buffalo Bills (12-5) at Denver Broncos (14-3)
Game Details: Saturday, January 17, 4:30 p.m. EST
Location: Empower Field at Mile High
Denver, CO
Where to Watch: CBS

AFC Divisional Matchup

With the NFL playoffs heating up with divisional weekend, the Buffalo Bills are looking to keep their momentum going to the Super Bowl against the Denver Broncos in Mile High. The Broncos are hosting the Bills in their first home playoff game since 2016, and could have a strong game for bettors on Saturday for the divisional round. Bettors could see a classic between the Denver Broncos and the Buffalo Bills in an epic divisional match-up.

Betting Odds

Team Spread Money Line Total
Buffalo Bills+1.5+102Over 46.5
Denver Broncos-1.5-116Under 46.5

** Odds Subject to Change – Courtesy of FanDuel**

Tale of The Tape

Buffalo BillsTeam Stats – Avg Per GameDenver Broncos
27.0Points Per Game23.6
261.0Passing Yards Per Game223.9
79.0Rushing Yards Per Game118.7
24.0Opponents Points Per Game Allowed18.3
205.0Opponents Pass Yards Allowed 187.2
154.0Opponents Rush Yards Allowed 91.1

Statistics from various online sources and courtesy of ESPN and FOX Sports

Key Details

Eagles vs Broncos
Oct 5, 2025; Philadelphia, Pennsylvania, USA; Denver Broncos quarterback Bo Nix (10) and Philadelphia Eagles quarterback Jalen Hurts (1) meet after the game at Lincoln Financial Field. Mandatory Credit: Eric Hartline-Imagn Images

Buffalo Bills

This season for the Buffalo Bills has been intense, with the injuries and expectations being high. Buffalo this season has been inconsistent, losing to quality defenses. The Bills’ win against the Jaguars was an amazing game from Josh Allen, who has carried the team on his back this season. Allen is coming off a strong regular season and a great Wild Card game, and could carry the momentum against the Broncos on Saturday.

The Bills’ defense has been playing well, with a great game from Tre’Davious White with two tackles and three pass deflections. While the Broncos’ offense is strong, the Bills could use their playoff experience to get a win against them in Denver to get close to a Super Bowl

Denver Broncos

The Buffalo Bills are playing well and have momentum heading into their match-up against the Denver Broncos. Denver during the regular season has been having a strong season with a resurgent offense, with Bo Nix having a great season. Nix and the offense have been playing well, scoring 23 points a game. The Broncos’ defense is also having another strong season, allowing 18 points a game and allowing 187 passing yards a game.

Denver’s defense has a strong secondary with Pat Surtain II leading the group. Denver could have their first playoff win since 2016 with their defense and winning in close games against a weak Bills team to get closer to the Super Bowl and have another strong run.

Prediction

While the Buffalo Bills are coming into Denver hot, the Denver Broncos could win this game in ugly fashion. The Bills defense has been suffering from injuries all season, and even with White having a strong game at Jacksonville, the Broncos’ wide receivers could play against the Bills secondary. Along with the Bills’ defensive flaws, the offense could have a difficult time against the Broncos’ defense, which has been playing well in the regular season, and could dominate the Bills in the playoffs.

While the Broncos are going to win this game, bettors should not have them covering due to them playing close games all season, and could be in the under due to both offenses being inconsistent at times this season.

Final Pick

Denver Broncos +1.5

Under 46.5

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