If you’re a fantasy football fan, it doesn’t get much better than this with the 49ers at Eagles. Two NFC powerhouses collide in what feels like a playoff-caliber matchup, loaded with elite talent on both sides of the ball. All eyes will be on Brock Purdy to see if he can work his magic against a physical Eagles defense, while Jalen Hurts and company look to answer back in a game packed with fantasy implications.
Quarterbacks
Brock Purdy — (Strong Start)
Purdy is playing with supreme confidence right now, commanding the offense and distributing the ball efficiently. With Christian McCaffrey easing pressure and multiple pass-catchers capable of winning their matchups, Purdy is set up to succeed. Expect poise, smart decisions, and sneaky upside in this one.
Jalen Hurts — (Strong Start)
The 49ers’ defense is no joke, which means Hurts may need to lean heavily on his legs to make his fantasy impact. That’s exactly what keeps his floor so high. Even if passing lanes tighten, his rushing ability and red-zone usage make him a fantasy cornerstone.
Running Backs
Christian McCaffrey — (Must Start)
CMC needs to have another big day, and history says he will. His versatility is the key to keeping the Eagles’ defense honest, and he’s the engine that makes everything work for San Francisco. Expect heavy usage, high efficiency, and elite fantasy production.
Saquon Barkley — (Strong Start)
Barkley has the ability to flash last season’s form at any moment. If Philadelphia commits to establishing the run, Saquon could be the difference-maker. His burst and big-play potential make him a strong start in all formats this week.
Wide Receivers
A.J. Brown — (Strong Start)
Brown has been a focal point to end the season, and that won’t change here—even in a tough matchup. His physicality and red-zone presence keep his touchdown upside intact, making him hard to bench in a game of this magnitude.
DeVonta Smith — (Strong Start)
Smith draws the more favorable matchup against the No. 2 corner and has the speed and route-running to exploit it. He’s a strong bet to deliver solid production and has the ability to find the end zone.
49ers’ Jauan Jennings, Brock Purdy ‘found our stride’ entering stretch run via The Mercury News
Jauan Jennings — (Flex Play)
Jennings is coming off a big performance that included a touchdown, and San Francisco may need him again. He’s not a lock, but he’s a viable flex option in deeper formats if he continues to see meaningful targets.
Tight Ends
George Kittle — (Must Start)
This is a matchup nightmare for Philadelphia. With the Eagles’ top corners focused on the outside receivers, Kittle should find plenty of space inside. His combination of strength, speed, and red-zone usage makes him one of the top tight end plays of the week.
Dallas Goedert — (Strong Start)
Goedert remains Hurts’ security blanket and is heavily utilized near the goal line. Against a tough defense, expect Hurts to lean on him in critical moments. Strong TE1 upside here.
Sleeper: Jake Tonges — (Deep-League Sleeper)
Tonges has quietly been a reliable underneath option for Purdy. While he’s not a mainstream fantasy play, his role as a security blanket gives him sneaky PPR appeal in very deep formats.
Fantasy Outlook
This game has all the ingredients of a fantasy classic: elite quarterbacks, superstar running backs, and matchup-driven pass-catchers. McCaffrey and Kittle headline the must-starts, while Hurts’ rushing upside keeps him firmly in QB1 territory. If Purdy continues his confident play, this could turn into a fantasy goldmine.
Buckle up, this one deserves every bit of “Game of the Week” hype.
