Seattle Seahawks at San Francisco 49ers Preview, Prediction & Odds | Week 18, 2025

Seattle seahawks
Seattle Seahawks (13-3) at San Francisco 49ers (12-4)
Game Details: Saturday, January 3, 8:00 PM. EST
Location: Levi’s Stadium, Santa Clara, CA
Where to Watch: ABC/ESPN

Week 18 Matchup

The NFC West and the number one seed are on the line this Saturday night, and bettors could win big in this preview of the Seattle Seahawks and the San Francisco 49ers in this NFC West showdown. This season has been great for fans and bettors, and Saturday night could be the start of something amazing with the Niners and Seahawks playing for their playoff lives. Bettors could win a lot against Vegas this weekend, but it starts with tonight’s game between the Seattle Seahawks and the San Francisco 49ers.

Betting Odds

Team Spread Money Line Total
Seattle Seahawks-1.5-118Over 47.5
San Francisco 49ers+1.5+100Under 47.5

** Odds Subject to Change – Courtesy of FanDuel**

Tale of The Tape

Seattle SeahawksTeam Stats – Avg Per GameSan Francisco 49ers
29.4Points Per Game27.1
231.0Passing Yards Per Game252.3
119.8Rushing Yards Per Game235.6
18.1Opponents Points Per Game Allowed22.4
198.6Opponents Pass Yards Allowed 110.3
94.4Opponents Rush Yards Allowed 103.3

Statistics from various online sources, courtesy of ESPN and FOX Sports

Key Details

San Francisco 49ers
Sep 22, 2024; Inglewood, California, USA; San Francisco 49ers quarterback Brock Purdy (13) throws a pass in the second half at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Seattle Seahawks

The Seattle Seahawks are nearing the playoffs and could have a strong game against their hated rival in Saturday night’s prime-time matchup. Seattle has had a strong year on defense, ranking as the best this season. The Seahawks‘ secondary has been playing well, with a top-tier defense along with a strong defensive front. There is also the Seahawks offense being a solid unit, with Sam Darnold having a solid season for the team. Along with a great running game, the Seahawks could have a great game against their rivals for the NFC West. 

San Francisco 49ers

While the Seattle Seahawks are a dangerous team, the San Francisco 49ers are also having a strong season despite the injuries. The Niners’ offense has been excellent, with Christian McCaffrey having a strong and healthy season. San Francisco’s running game has been strong with being a top-tier unit along with the passing offense. The Niners‘ offense has been solid with either Brock Purdy or Mac Jones this season, being good under center. San Francisco will also be at home to end the season, and it won last week in a thriller against the Bears. This season has been chaos for the NFL and could end with a bang for the Niners.

Prediction

The season has been intense for bettors and fans in the NFC West, and this showdown between the Seattle Seahawks and San Francisco 49ers could be a close one, with Vegas calling it that way. While both teams are coming off strong wins, the Niners are the hotter team, having won six straight, along with beating the Bears last week. There is also the notion of the Niners beating the Seahawks in week one, and with the roster, while not fully healthy, could beat them again. With Vegas having this as a coin flip, the Niners are a safe bet, even with being an underdog, and could have the under due to both defenses being elite.

Final Pick

San Francisco 49ers +1.5

Over – Under

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