The Jacksonville Jaguars have emerged as this year’s surprise story, reshaping the AFC landscape. Meanwhile, the Cardinals are struggling and may be forced into a pass-heavy script, creating fantasy opportunities across multiple positions. Week 12 could see both QBs and skill players post significant numbers.
START ’EM

Trevor Lawrence — QB, Jaguars
Lawrence has found the end zone in recent weeks and continues to produce efficiently. Expect 230+ yards and at least 1 TD. Reliable QB1 option in all formats.
Jacoby Brissett — QB, Cardinals
Brissett’s 400-yard explosion last week proves he thrives in high-volume passing games. Expect another strong outing if the Cardinals fall behind early. QB1/FLEX for deeper leagues.
Travis Etienne — RB, Jaguars
ETN splits carries with Bhayshul Tuten but is still the main back. Higher touchdown volume and usage make him a confident start. RB1 upside.
Trey McBride — TE, Cardinals
McBride has been efficient and a primary red-zone target. TE1/2 potential depending on league depth.
Why Bhayshul Tuten Might Just Be Getting Started for Jaguars – Andy Guach via SI.com
Bhayshul Tuten — RB, Jaguars
True split role, but Tuten has shown the ability to produce. Could steal a score in limited touches. FLEX-worthy.
Jakobi Meyers — WR, Jaguars FLEX
Meyers’ emergence has been perfectly timed. Expect 5–6 catches for ~70 yards. High-volume FLEX option.
Michael Wilson — WR, Cardinals
Wilson had a solid outing last week when Arizona was forced to pass. Another high-target game is likely if the game script continues.
Bam Knight — RB, Cardinals
Demercado is out, giving Knight a clear path to work. Should see goal-line touches and short-yardage usage.
Greg Dortch And 3 More Fantasy Football Wide Receiver Streamers For Week 12 – Ryan Shea via SI.com
Greg Dortch — WR, Cardinals (Sleeper)
Deep-league sleeper. If the Cardinals fall behind and Brissett airs it out, Dortch could see multiple targets and a score. Worth the bench in 12+ team leagues.
FINAL TAKEAWAY
This game is likely to be high-scoring and QB-friendly, especially if the Cardinals fall behind early.
• Jaguars: Lawrence and Etienne anchor the fantasy upside.
• Cardinals: Brissett, McBride, and emerging WRs like Meyers/Wilson provide PPR and touchdown upside.
• Deep leagues: Dortch is the perfect sleeper if Arizona is forced to air it out.
Expect a shootout with multiple fantasy-friendly options on both sides.
