If your fantasy team survived Week 10 without a key player tearing, spraining, or straining something, consider yourself a unicorn heading into Week 11.
For the rest of us mortals, it’s time to stare into the abyss of the waiver wire and pray for a miracle. The 2025 fantasy football injuries are piling up, and it’s turning league championships into a war of attrition. Let’s sift through the wreckage and see who’s down, who’s out, and who might just save your season.
Quarterback Injuries Chaos: Concussions and Comebacks

Just when you thought the quarterback landscape couldn’t get any messier, Week 10 delivered another round of blows. Jaxson Dart of the Giants got his bell rung and was unceremoniously dumped into the concussion protocol. Starting any Giants player was already a questionable life choice, but with Dart sidelined, it’s a full-blown fantasy nightmare. Good luck finding a reliable replacement in that dumpster fire.
Meanwhile, the great hope of Cincinnati, Joe Burrow, might be plotting a heroic return. After suffering what was thought to be a season-ending Grade 3 turf toe injury, whispers from the Bengals camp suggest he could be back for the fantasy playoffs, maybe as soon as Week 13. Is it a desperate smokescreen or a league-winning comeback story? Betting on it feels like a roll of the dice, but if you have a spare IR spot, stashing Burrow could be the high-risk, high-reward play that defines your season. His return would send the ageless Joe Flacco back to the bench, ending one of the most bizarrely effective fantasy runs in recent memory.
The Running Back Injuries Graveyard for Week 11

The running back position continues to be a minefield of disappointment. J.K. Dobbins can’t catch a break, now dealing with a foot injury that has him seeking a second opinion. When a player starts shopping for doctors, it’s rarely good news. While we wait for the verdict, rookie RJ Harvey is lurking in the shadows. He’s got the talent to be an RB2, but Broncos head coach Sean Payton seems to trust him about as far as he can throw him. It’s a classic coaching conundrum that could capsize Harvey’s fantasy value before it even sets sail.
In Arizona, another back went down. Bam Knight suffered an ankle injury, leaving the Cardinals with a backfield held together by duct tape and wishful thinking. This opens the door for Emari Demercado, a back with breakaway speed who suddenly finds himself with a golden opportunity. If Knight misses time, Demercado could be a sneaky flex play against the 49ers. Keep your ear to the ground for updates, because this situation is as fluid as they come.
Wide Receiver Woes and Waiver Wire Wonders

The hits just keep coming for wide receivers. The Jets’ Garrett Wilson aggravated a nagging knee injury and is now expected to miss multiple weeks. In his absence, the targets have to go somewhere, and rookie tight end Mason Taylor might just be the unlikely beneficiary. It’s a long shot, but in this injury-plagued season, we’re all desperate.
In Los Angeles, Davante Adams is battling an oblique strain, and while he’s hopeful to play, don’t be surprised if he sits out Week 11. If he does, it’ll be a free-for-all for targets among the likes of Jordan Whittington and Xavier Smith. It’s a messy situation that’s probably best avoided unless you’re truly desperate. Elsewhere, the Cardinals lost Zay Jones for the season to a suspected Achilles rupture, a brutal end to his campaign.
Tight End Turmoil Injuries

The tight end position is notoriously thin, and injuries to key players are making it even shallower. Buffalo’s Dalton Kincaid is nursing a hamstring strain and is considered “week-to-week,” which is coach-speak for “don’t count on him.” His absence makes Dawson Knox a viable streaming option and a low-end TE1. In Los Angeles, Oronde Gadsden II is day-to-day with a bruised quad. If he’s out, it’s anyone’s guess how his targets will be split.
The injury report is a grim read, but it’s also where fantasy championships are won. Stay vigilant, play the waiver wire aggressively, and hope that your roster is the last one standing when the dust settles.
