Kansas City Chiefs vs. Los Angeles Chargers Preview, Prediction & Odds | Week 1, 2025

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Nothing says Friday Night Lights like an NFL game from Brazil for Chargers vs. Chiefs. There is no truth to the rumor that the NFL is trying to broaden Taylor Swift’s appeal by hosting this game in South America. They are actually more selfish than that, trying to globalize the NFL somewhere other than across the pond.

The Chargers will win in Brazil

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From: FanDuel

By the way, savor this Friday Night game, as it is unlikely to happen next year. In case you missed it on your history test years ago, the Sports Broadcasting Act of 1961 prohibits NFL games on the second week of September through the second week of December. For the last two years, Labor Day weekend has been early enough that the Friday game is in the first week of September.

But that test question will not make you any money. By using the following advice, you may make more in one day than your history teacher does in one day. However, be sure to bet only what you can afford to lose.

Take Jim Harbaugh for Week 1 Openers

​This seems to be the type of game that says, “Don’t bet against Jim Harbaugh.” Harbaugh’s arrival in Los Angeles has injected new life into a franchise that’s been tantalizingly close to greatness for years. The Michigan legend brings his 5-0 record in NFL season openers with both the Chargers and the 49ers.

​If the Chargers can execute the Eagles’ game plan that constrained Patrick Mahomes in the Super Bowl, it should be enough to allow Herbert to shine and score enough for the win.

On offense, the narrative surrounding Justin Herbert heading into 2025 feels almost unfair. Here’s a quarterback with a cannon arm, elite pocket presence, and the physical tools that scouts dream about. Yet the last image burned into fans’ minds is Herbert throwing four interceptions against Houston in last season’s playoff meltdown.

The Chiefs’ secondary, while talented, isn’t the imposing unit it once was. Trent McDuffie remains elite, but there are exploitable matchups across the field. If Herbert can find his rhythm early, and more importantly, avoid the costly mistakes that plagued his playoff performance, the Los Angeles Chargers offense has the firepower to keep pace with Mahomes.

Prediction: Pick the Los Angeles Chargers

Final thoughts: We looked and did not find a betting line on the first player to spit – and the first player to retaliate. Please note that the betting line in this story may change slightly or significantly.

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